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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Hypoxia preconditioned plasma ： ウィキペディア英語版 Hypoxia preconditioned plasma Hypoxia preconditioned plasma or hypoxia pre-conditioned plasma (abbreviated as HPP), is the term used to describe the (cell-free) plasma obtained after extracorporeal conditioning (i.e. culturing) of anticoagulated blood under physiological temperature (37 °C) and physiological hypoxia (1–5 %O2). Letting the blood to coagulate before conditioning it under the same conditions yields hypoxia preconditioned serum (abbreviated as HPS). Blood conditioning is typically carried out over 2 to 4 days.〔 Since blood cells sediment over time, during conditioning, HPP and HPS can be passively separated from the blood cell components without centrifugation, a requirement for sampling normal blood plasma and serum . Hypoxia precondtioned blood products, such as HPP and HPS (in Europe marketed as HYPPP®〔)) are currently developed as therapies for wound regeneration and skin rejuvenation. ==Development== Cellular hypoxic preconditioning has been employed to obtain complex, and physiological, secretomes rich in angiogenic factors. Hypoxic preconditioning can be carried out by culturing cells in an oxygen-control incubator, or by allowing cells to create a natural hypoxic microenvironment through their own oxygen consumption. For example, skin fibroblasts that were cultured in 3D collagen matrices at high densities generated hypoxia within the matrix core, which led to an upregulation of VEGF expression. Delivery of such hypoxia-induced factors in vivo has proved to be effective in supporting the vascularization, oxygenation and host-integration of subcutaneously-placed collagen implants. Exposing peripheral blood cells to hypoxic stress stimulation has been shown to promote upregulation of expression of angiogenic growth factors (e.g. VEGF).〔 Controlled release of peripheral blood cell-derived factor mixtures was found to induce directional microvessel growth in vitro.〔 The term 'hypoxia preconditioned plasma' was first described by Hadjipanayi & Schilling, when they proposed that hypoxia can provide a useful tool for enhancing the angiogenic potential of blood plasma by generating compositions based on blood cell natural responses to a wound-like microenvironment. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Hypoxia preconditioned plasma」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.